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Perilla (Perilla frutescens)
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Perilla/Drug Interactions:- BarbituatesBarbituates: Theoretically, perilla frutescens may prolong hexobarbital-induced sleep, due to the isolation of dillapiol (13). Isolation of other potentially sedative constituents has been documented (14).
- Cholesterol-lowering drugsCholesterol-lowering drugs: Theoretically, perilla may lower HDL-cholesterol levels based on animal study.
- NSAIDSNSAIDS: Theoretically, perilla may suppress indomethacin-induced effects, due to a change in fatty acid and eicosanoid status (15).
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Perilla/Herb/Supplement Interactions:- Beta-caroteneBeta-carotene: Theoretically, the results from an animal study suggest that the combination of perilla and beta-carotene may reduce the risk of colon cancer (16).
- Cholesterol-lowering herbs and supplementsCholesterol-lowering herbs and supplements: Theoretically, perilla may lower HDL-cholesterol levels based on animal study.
- Fish oilFish oil: Theoretically, use of fish oil and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
- Omega-3 fatty acidsOmega-3 fatty acids: Theoretically, use of omega-3 fatty acid sources (flax oil, walnut oil, soybean oil) other than perilla, with perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
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Perilla/Food Interactions:- FishFish: Theoretically, use of fish and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
- FlaxFlax: Theoretically, use of flax and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
- Omega-3 fatty acid-containing foods (general)Omega-3 fatty acid-containing foods (general)
: Theoretically, use of omega-3 fatty acid-containing foods and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
- WalnutsWalnuts: Theoretically, use of walnuts and perilla would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
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Perilla/Lab Interactions:- FibrinogenFibrinogen: Fibrinogen levels did not change after ten months on a perilla oil enriched diet (17).
- GlucoseGlucose: Glucose levels did not change after ten months on a perilla oil enriched diet (17).
- InsulinInsulin: Insulin levels did not change after ten months on a perilla oil enriched diet (17).
- HbA1cHbA1c: HbA1c levels did not change after ten months on a perilla oil enriched diet (17).
- LipoproteinsLipoproteins: Total cholesterol and triglycerides did not change after ten months on a perilla oil enriched diet (17). Triglyceride and cholesterol lowering was observed in animal models (18; 19; 20). Based on results in animal studies, perilla oil may result in a decrease in HDL-cholesterol (21).
- PAI-1PAI-1: PAI-1 concentration did not change after ten months on a perilla oil enriched diet (17).
- Platelet countPlatelet count: Platelet count or aggregation did not change after ten months on a perilla oil enriched diet (17).
- Prothrombin timeProthrombin time: Prothrombin time did not change after ten months on a perilla oil enriched diet (17).
- Serum fatty acidsSerum fatty acids: In elderly subjects, alpha-linolenic acid increased in total serum lipid from 0.8 to 1.6% after three months on a perilla oil enriched diet. Eicosapentaenoic acid and docosahexaenoic acid increased after ten months on a perilla oil enriched diet (2.5 to 3.6% and 5.3 to 6.4%, respectively) (17).
- Thromboplastin timeThromboplastin time: Thromboplastin time did not change after ten months on a perilla oil enriched diet (17).
- Tumor necrosis factorTumor necrosis factor: In vitro, a polysaccharide isolated from perilla, as well as perilla juice, has been found to increased tumor necrosis factor production (22; 23). It is not clear if this has clinical relevance.
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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